Biological and Medical Applications of Materials and Interfaces
- Yuanyuan Huang
Yuanyuan Huang
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
More by Yuanyuan Huang
- Qiunan Li
Qiunan Li
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
More by Qiunan Li
- Fei He
Fei He
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
More by Fei He
- Tao Yang
Tao Yang
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
More by Tao Yang
- Qing Zhou*
Qing Zhou
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu 610051, China
*Email: [emailprotected]
More by Qing Zhou
- Yaxin Zheng*
Yaxin Zheng
Key Laboratory of Structure-Specific Small Molecule Drugs at Chengdu Medical College of Sichuan Province, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China
*Email: [emailprotected]
More by Yaxin Zheng
- Yang Li*
Yang Li
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
*Email: [emailprotected], [emailprotected]
More by Yang Li
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
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https://pubs.acs.org/doi/10.1021/acsami.5c01634
Published April 26, 2025
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Abstract
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In this study, we reported a cationic azobenzene (Azo) tag to increase the retention of camptothecin (CPT) prodrugs in liposomes driven by π–π stacking interaction between Azo. Compared with a cationic CPT prodrug without Azo, the liposome-encapsulating Azo-linked CPT prodrugs (AzoCPT-Lips) exhibited slower prodrug leakage in plasma and a longer blood circulation time in mice. The AzoCPT-Lips had a high encapsulation efficiency (95%), loading capacity (20%, by weight), and good storage stability. The AzoCPT was efficiently taken up by 4T1 tumor cells (100-fold higher than CPT) and readily converted into active CPT in the cytoplasm to exert 10-fold higher cytotoxicity than free CPT. More importantly, AzoCPT-Lips resulted in 5–20 times higher tumor distribution of active CPT than that of CPT solution or those in other tissues, which further led to more potent antitumor activity and lower toxicities in the 4T1 breast cancer xenograft. Such a cationic Azo tag represents an effective strategy for developing liposomal antitumor drugs with improved antitumor efficacy.
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© 2025 American Chemical Society
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 26, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
Request reuse permissions
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